UNRAVELLING ANTIGENIC CROSS-REACTIONS TOWARD THE WORLD OF CORONAVIRUSES: EXTENT OF THE STABILITY OF SHARED EPITOPES AND SARS-COV-2 ANTI-SPIKE CROSS-NEUTRALIZING ANTIBODIES

The human immune repertoire retains the molecular memory of a very great diversity of target antigens (epitopes) and can recall this upon a second encounter with epitopes against which it has previously been primed.Although genetically diverse, proteins of coronaviruses exhibit sufficient conservation to lead to antigenic cross-reactions.In this re

Growth-associated protein 43 (GAP43), is a strictly conserved protein among vertebrates implicated in neuronal IONIC ADDITIVE ASH development and neurite branching.Since GAP43 structure contains a calmodulin-binding domain, this protein is able to bind calmodulin and gather it nearby membrane network, thus regulating cytosolic calcium and consequen

Mechanical defects and partial discharge (PD) defects can appear in the indoor switchgear of substations or distribution stations, making the switchgear a safety hazard.However, traditional acoustic methods detect and identify these two types of defects separately, ignoring the general recognition of audio signals.In addition, the process of using